Chromatin: Hanging on to histones

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Chromatin: Hanging on to histones

The core histones have long been known to have an important role in the packaging of DNA into nucleosomes. Today, nucleosome assembly is recognized as an integral component of both transcriptional activation and repression [1]. Transcriptional control is mediated through the assembly of extensive nucleoprotein structures containing both conventional transcription factors and architectural facto...

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Patrick Cramer is a professor of Biochemistry at the Ludwig Maximilians University of Munich, Germany, and head of the Gene Center Munich. He is a structural biologist who has contributed to our understanding of the structure and function of RNAP II from yeast and its associated factors. In a recent study, his laboratory described the structure of RNAP II in complex with the initiation factor T...

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Specific patterns of acetylation of the core histones are associated with specific structures and functions of chromatin. A basis for the specificity of acetylation is now apparent in the recent crystal structures of two acetyltransferases.

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Chromatin, Histones, and Epigenetic Tags

POPULÄRVETENSKAPLIG SAMMANFATTNING LIST OF PUBLICATIONS LIST OF ABBREVIATIONS INTRODUCTION 15 Chromatin History and Research 16 Nobel Prizes Related to Chromatin 19 AIMS OF THE STUDY 21 CHROMATIN STRUCTURE 23 DNA 23 Composition of DNA 23 The Nucleosome 26 Location of Linker Histones 27 Higher-Order Chromatin Structure 28 Euchromatin and Heterochromatin 30 THE HISTONES 31 Histone Variants 32 Cor...

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ژورنال

عنوان ژورنال: Current Biology

سال: 1996

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(02)00465-7